p16 expression and breast cancer risk in women with atypical hyperplasia
نویسندگان
چکیده
From Division of Biochemistry/Molecular Biology, Mayo Clinic in Jacksonville, FL; Departmento de Oncologia, Clinica Universitaia de Navarra, Navarra, Spain; Department of Laboratory Medicine and Pathobiology and; Department of Medical Biophysics, Campbell Family Institute for Breast Cancer Research, University of Toronto, Canada; 5 Division of Medical Oncology, Department of Anatomic Pathology, Division of Biomedical Statistics and Informatics Mayo Clinic in Rochester, MN; Department of Pathology, University of California San Francisco.
منابع مشابه
Molecular biomarkers of risk in premalignancy and breast cancer prevention.
About 50,000 U.S. women are diagnosed with breast atypical hyperplasia each year, giving them about a six-fold increased relative risk of developing invasive breast cancer (IBC) compared with age-matched controls. Still, only a small fraction of patients with atypical hyperplasia ever progress to IBC, which is a major reason why a large majority do not participate in breast cancer prevention, d...
متن کاملPnm-22: Breast Screening in Patient Undergoing ART Cycles
The fact that the development of breast cancer is linked to repeated or sustained exposure to high blood estrogen levels has raised obvious concern that reproductive hormones particularly estrogen, might increase the risk of breast cancer development. While, the general consensus is that overall; IVF is not associated with an increased risk for development of breast cancer, a recent report publ...
متن کاملERβ expression and breast cancer risk prediction for women with atypias.
Estrogen receptor (ER) β is highly expressed in normal breast epithelium and a putative tumor suppressor. Atypical hyperplasia substantially increases breast cancer risk, but identification of biomarkers to further improve risk stratification is needed. We evaluated ERβ expression in breast tissues from women with atypical hyperplasia and association with subsequent breast cancer risk. ERβ expr...
متن کاملEstrogen receptor expression in atypical hyperplasia: lack of association with breast cancer.
Estrogen receptor (ER) is expressed in normal and malignant breast epithelium, and expression levels have been found to increase with age in normal breast epithelium but not in atypical hyperplasia (AH) and carcinoma in situ. Here we assess ER expression in AH and its association with later breast cancer. ER expression was assessed immunohistochemically in archival sections from 246 women with ...
متن کاملAssociation between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer.
BACKGROUND The cyclooxygenase-2 (COX-2) enzyme, which is induced by inflammatory and mitogenic stimuli, plays a protumorigenic role in several human cancers. COX-2 is overexpressed in invasive and in situ breast cancers. Atypical hyperplasia in breast tissue, although benign, is associated with a high risk of breast cancer. We investigated whether COX-2 overexpression in atypical hyperplasia is...
متن کامل